New paper in Advanced Functional Materials
Hashim and colleagues have recently published in Advanced Functional Materials a new method to fabricate size- and shape- controlled porous silicon (pSi) nanoparticles to be used as targeted anticancer drug delivery carriers. The method, which utilizes a simple colloid nanosphere lithography pSi coupled with Metal Assisted Chemical Etching (MACE), results in nanoparticles with discoidal shape, hence termed nanodiscs (NDs). Their work exhibits how the pSi NDs are highly porous, degradable and can be loaded with a large payload of the anticancer drug camptothecin (CPT). Moreover, they can be bioconjugated with a cell-specific antibody, showing targeted drug delivery by selective attachment and subsequent killing of the target cells. Overall, their study opens new vistas for the field of cancer nanovectors.
You can find more in: Advanced Functional Materials, doi:10.1002/adfm.201403414