New paper in ACS Applied Materials & Interfaces
Check out our new ACS Applied Materials & Interfaces paper on “Rapid Detection of Anabolic and Narcotic Doping Agents in Saliva and Urine by Means of Nanostructured Silicon SALDI Mass Spectrometry” by Raj!
Our publication explores nanostructured silicon as a new technique to detect doping in sport.
See the abstract below:
Novel doping agents and doping strategies are continually entering the market, placing a burden on analytical methods to detect, adapt, and respond to subtle changes in the composition of biological samples. Therefore, there is growing interest in rapid, adaptable and ideally confirmatory analytical methods for the fight against doping. Nanostructured silicon (nano-Si) based surface-assisted laser desorption/ionisation mass spectrometry (SALDI-MS) can effectively address this need, allowing fast and sensitive detection of prohibited compounds used in sport doping. Here we demonstrate detection of growth hormone peptides, anabolic-androgenic steroids, and narcotics at low concentrations directly from biological matrices. Molecular confirmation was performed using the fragmentation data of the structures, obtained with the tandem mass spectrometry capabilities of the SALDI instrument. The obtained data were in excellent agreement with leading triple quadrupole liquid chromatography mass spectrometry instruments. Furthermore, nano-Si SALDI-MS has the capacity for high-throughput analysis of hundreds of biological samples, providing opportunities for real-time MS analysis at sporting events.